Krishnendu Guin

The paper identifies molecular regulators of centromere distribution by screening nuclear proteins and shows that mitosis influences interphase genome organization.

The paper develops a framework to quantitatively analyze spatial centromere distribution patterns using clustering metrics and modeling techniques, identifying Ripleys K Score as the most accurate metric.

HiTIPS provides a flexible, open-source platform for high-throughput image analysis in cell biology, supporting customization and integration of new algorithms for tasks like segmentation, tracking, and quantification.

The paper investigates how spatial inter-centromeric interactions facilitated the emergence of new centromeres in Candida species by analyzing genome structure and evolutionary transitions.

This study shows Orc4 stabilizes centromeric chromatin by interacting with CENPA and Mcm2, and its spatiotemporal localization is crucial for kinetochore stability in C. albicans.