Author

Caoimhe E. O’Brien

University College DublinORCID 0000-0002-7730-004XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:yeast· 5 Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Research Focus:phylogenetics / evolution· 2 Research Focus:benchmarking· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Geraldine ButleriD· 5 shared Aisling Y. CoughlaniD· 2 shared Eoin Ó CinnéideiD· 2 shared Kenneth H. WolfeiD· 2 shared Mihaela OlaiD· 2 shared Alexander DouglassiD· 1 shared Amartya SanyaliD· 1 shared Benjamin OffeiiD· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersGenomics

Geraldine ButlerORCID

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Author profile →

5 papers

Recent·Most cited

Identification of a novel Candida metapsilosis isolate suggests ongoing hybridization.

Caoimhe E. O’Brien, Bing Zhai, Mihaela Ola, Eoin Ó Cinnéide, Ísla O’Connor, Thierry Rolling, Edwin Miranda, N. Esther Babady, Tobias M. Hohl, Geraldine Butler

The paper identifies a new C. metapsilosis isolate resulting from a separate hybridization event, showing distinct genomic features compared to previously known isolates.

bioRxiv · Jul 15, 2021 · PreprintGenomics

Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.

Caoimhe E. O’Brien, João Oliveira-Pacheco, Eoin Ó Cinnéide, Max A. B. Haase, Chris Todd Hittinger, Thomas Richard Rogers, Óscar Zaragoza, Ursula Bond, Geraldine Butler

This study uses whole genome sequencing and phenotyping to analyze 77 C. tropicalis isolates, identifying hybrid lineages and a genomic variant affecting nitrogen utilization.

PLoS Pathogens · Mar 31, 2021Peer-reviewedGenomics

Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

Krishnendu Guin, Yao Chen, Radha Mishra, Siti Rawaidah Binte Mohammad Muzaki, Bhagya C. Thimmappa, Caoimhe E. O’Brien, Geraldine Butler, Amartya Sanyal, Kaustuv Sanyal

The paper investigates how spatial inter-centromeric interactions facilitated the emergence of new centromeres in Candida species by analyzing genome structure and evolutionary transitions.

eLife · May 29, 2020Peer-reviewedGenetics

Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis

Mihaela Ola, Caoimhe E. O’Brien, Aisling Y. Coughlan, Qinxi Ma, Paul D. Donovan, Kenneth H. Wolfe, Geraldine Butler

The paper reports polymorphic centromere locations in Candida parapsilosis, showing natural movement between sites without significant DNA sequence changes.

Genome Research · May 1, 2020Peer-reviewedGenomics

Coverage-versus-Length plots, a simple quality control step for de novo yeast genome sequence assemblies

Alexander Douglass, Caoimhe E. O’Brien, Benjamin Offei, Aisling Y. Coughlan, Raúl A. Ortiz‐Merino, Geraldine Butler, Kevin P. Byrne, Kenneth H. Wolfe

The paper introduces Coverage-versus-Length plots to assess de novo yeast genome assemblies, identifying contaminants and atypical scaffolds through coverage and length analysis.

G3 Genes Genomes Genetics · Jan 23, 2019Peer-reviewedGenomics