Kaustuv Sanyal

Terminator-dependent facilitated recycling of RNA polymerase III couples transcriptional activation and chromatin remodeling in vivo

The paper shows that transcription terminators facilitate RNA polymerase III recycling, enhancing chromatin transcription and linking transcriptional activation with chromatin remodeling in vivo.

Elevated Levels of Mcm7 Disrupt Microtubule and Nucleolar Homeostasis to Drive Genome Instability and Cell Death

This study shows that elevated Mcm7 levels disrupt microtubule and nucleolar homeostasis, leading to genome instability and cell death in yeast, with implications for human cancer.

Organization principles of dynamic three-dimensional genome architecture associated with centromere clustering states

The paper investigates how centromere clustering states in Cryptococcus neoformans influence 3D genome architecture during the cell cycle, revealing unique organizational principles.

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

This study shows that Sgo1 maintains SAC signals in Cryptococcus neoformans by regulating Aurora B kinase and PP1 levels at kinetochores, independent of Bub1 kinase activity.

The experimentally evolved fluconazole-resistant Clade II isolates of Candidozyma auris exhibit a distinct lipid compositional landscape, highlighting intra-clade sphingolipid heterogeneity

This study compares sphingolipid profiles of fluconazole-resistant Candidozyma auris isolates to identify intra-clade lipid compositional differences linked to antifungal resistance.

Expansion microscopy reveals unique ultrastructural features of pathogenic budding yeast species

This study uses expansion microscopy to reveal unique sub-cellular structures in Candida albicans, showing a distinct SPB arrangement compared to Saccharomyces cerevisiae.

Functional Plasticity in Chromosome-Microtubule Coupling on the Evolutionary Time Scale

The paper identifies a conserved arginine residue in the Dam1 complex subunit Dad2 that is essential for viability in yeast but less so in fungi with regional centromeres, suggesting functional plasticity in chromosome-microtubule coupling.

Frequent transitions in mating-type locus chromosomal organization in Malassezia and early steps in sexual reproduction

This study identifies genomic transitions in mating-type locus organization in Malassezia and shows engineered strains exhibit hyphal development and upregulated mating-related genes.

Spindle pole body-associated Atg11, an autophagy-related protein, regulates microtubule dynamics essential for high-fidelity chromosome segregation

This study shows Atg11, an autophagy-related protein, regulates microtubule dynamics and chromosome segregation in yeast by affecting spindle pole body function and Kar9-dependent spindle positioning.

Functional and comparative genome analysis reveals clade-specific genome innovations in the killer fungus Candida auris

The paper identifies centromere structures and evolutionary changes in Candida auris and related species, revealing clade-specific karyotype innovations.

Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres

The paper investigates how spatial inter-centromeric interactions facilitated the emergence of new centromeres in Candida species by analyzing genome structure and evolutionary transitions.

Loss of centromere function drives karyotype evolution in closely related Malassezia species

The paper identifies centromere regions in Malassezia species and shows that centromere loss drives karyotype evolution by causing chromosome breakage and fusion.

Early diverging fungus Mucor circinelloides lacks centromeric histone CENP-A and displays a mosaic of point and regional centromeres

The paper investigates the absence of CENP-A in Mucor circinelloides, revealing a unique mosaic of point and regional centromeres.

Orc4 spatiotemporally stabilizes centromeric chromatin

This study shows Orc4 stabilizes centromeric chromatin by interacting with CENPA and Mcm2, and its spatiotemporal localization is crucial for kinetochore stability in C. albicans.

Cellular Dynamics and Genomic Identity of Centromeres in the Cereal Blast Fungus

This study identifies unusual centromere dynamics and maps centromere DNA sequences in the rice blast fungus Magnaporthe oryzae, revealing epigenetic specification of centromere function.

Identification and in silico analysis of the origin recognition complex in the human fungal pathogen Candida albicans

The paper identifies putative ORC homologs in Candida albicans and analyzes their domain architecture and 3D structure to understand their role in DNA replication.