BioengineeringbioRxivPreprint
Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot
Liyuan Zhu, Long Thành Nguyễn, Alexandra G. Bell…·Jared E. Toettcher
This paper develops OptoCas13d and ChemoCas13d variants of RfxCas13d that can be controlled by light or small molecules to modulate RNA cleavage with high spatial and temporal precision.
DOI 10.1101/2025.04.21.649818