Author

Long Thành Nguyễn

Princeton UniversityORCID 0000-0002-0061-9941Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Cameron MyhrvoldiD· 2 shared Jared E. ToettcheriD· 2 shared Piyush JainiD· 2 shared Akito Y. KawaharaiD· 1 shared Alexandra G. BelliD· 1 shared Anne FangiD· 1 shared Brandon M. ParkeriD· 1 shared Brianna L.M. PizzanoiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBioengineering

Cameron MyhrvoldORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Efficient Genome Editing with Chimeric Oligonucleotide-Directed Editing

Long Thành Nguyễn, Noah R. Rakestraw, Brianna L.M. Pizzano, Rajan Iyyappan, Cullen B. Young, Yujia Huang, Kate T Beerensson, Anne Fang, Sydney G Antal, Katerina V Anamisis, Coleen Michelle Deans Peggs, Jun Yan, Yangwode Jing, Jordan G. Lewis, Rebecca D. Burdine, , Piyush Jain

This paper introduces CODEMax and CODEMax(exo+) genome editing systems that enable efficient and precise search-and-replace editing in human cells with reduced off-target effects.

Nature Communications · Apr 13, 2026Peer-reviewedBioengineering

Multimodal control of Cas13 activity through domain insertion at an allosteric hotspot

Liyuan Zhu, Long Thành Nguyễn, Alexandra G. Bell, Kara M. Gillmann, Harrison R. Oatman, Jack Hariri, Cameron Myhrvold, Jared E. Toettcher

This paper develops OptoCas13d and ChemoCas13d variants of RfxCas13d that can be controlled by light or small molecules to modulate RNA cleavage with high spatial and temporal precision.

bioRxiv · Apr 21, 2025 · PreprintBioengineering

CRISPR-based diagnostics detects invasive insect pests

Pathour Rajendra Shashank, Brandon M. Parker, Santosh R. Rananaware, David M. Plotkin, Christian Couch, Lilia G. Yang, Long Thành Nguyễn, N. R. Prasannakumar, W. Evan Braswell, Piyush Jain, Akito Y. Kawahara

This paper develops a CRISPR-based diagnostic method using CO1 gene targeting to detect invasive moth pests with high accuracy and sensitivity.

Molecular Ecology Resources · Oct 27, 2023Peer-reviewedGenetics