Author

Sharon L. Freshour

Washington University in St. LouisORCID 0000-0001-6978-3515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Joshua F. McMichaeliD· 3 shared Kelsy C. CottoiD· 3 shared Malachi GriffithiD· 3 shared Obi L. GriffithiD· 3 shared Cody A. RamireziD· 2 shared Gavin P. DunniD· 2 shared Huiming XiaiD· 2 shared Megan M. RichtersiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBioinformatics

Joshua F. McMichaelORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 20, 2025

Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice

Mary H. Patton, Brett J.W. Teubner, Kristen T. Thomas…·Stanislav S. Zakharenko

This study identifies striatal hypercholinergic state and thalamostriatal disruption as causes of amotivation in a 22q11DS mouse model.

3 citations

mouseelectronic health records

𝕏 PostBluesky

BioinformaticsScience ImmunologyPeer-reviewedApr 7, 2023

Computational prediction of MHC anchor locations guide neoantigen identification and prioritization

Huiming Xia, Joshua F. McMichael, Michelle Becker‐Hapak…·Malachi Griffith

The paper predicts MHC anchor positions for 328 HLA alleles and shows that incorporating these improves neoantigen identification by correcting misclassified candidates in tumor samples.

30 citations

humanbulk RNA-seq

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BioinformaticsNature CommunicationsPeer-reviewedMar 22, 2023

RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer

Kelsy C. Cotto, Yang-Yang Feng, Avinash Ramu…·Malachi Griffith

RegTools identifies splice-associated variants in cancer by integrating genomic and transcriptomic data across 9,000 tumor samples, discovering 235,778 splicing events.

131 citationstop 1%

humanwhole-genome sequencing

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BioinformaticsNucleic Acids ResearchPeer-reviewedOct 23, 2020

✦ In-depth digest

Integration of the Drug-Gene Interaction Database (DGIdb) with open crowdsource efforts

Sharon L. Freshour, Susanna Kiwala, Kelsy C. Cotto…·Alex Handler Wagner

DGIdb 4.0 aggregates drug-gene interaction and druggability claims from 41 sources, adding crowd-sourced Drug Target Commons, Wikidata-based drug normalization, search-relative query scores, and NDEx export.

1,003 citationstop 1%

humanstatistical model

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