Anirudh Patir

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

This study examines how stroke alters myeloid cell composition and phenotypes in the brain, linking changes to cell origin, spatial organization, and brain connectivity.

Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis

This study uses scRNA-seq to identify cell types and gene signatures in developing worker honey bees, providing a first single-cell atlas of honey bee development.

Single-cell RNA-seq reveals CD16- monocytes as key regulators of human monocyte transcriptional response to Toxoplasma

The paper uses single-cell RNA sequencing to show that CD16- monocytes are key in the transcriptional response of human monocytes to Toxoplasma infection, revealing transcriptional heterogeneity and cytokine secretion patterns.

Graphia: A platform for the graph-based visualisation and analysis of complex data

Graphia is an open-source platform for graph-based analysis of complex biomedical data, offering visualization, transformation, and analysis tools for high-dimensional datasets.

Myeloid cell and transcriptome signatures associated with inflammation resolution in a model of self-limiting acute brain inflammation

The paper describes a model of self-limiting acute brain inflammation and identifies gene networks associated with inflammation resolution.

A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease

The paper defines a core transcriptional signature of human microglia through meta-analysis and shows its utility in identifying region-specific alterations in Alzheimer’s disease.