Author

Stefan Szymkowiak

UK Dementia Research InstituteORCID 0000-0002-2079-7104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:spatial domain detection· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Barry W. McColliD· 3 shared Jack BarringtoniD· 2 shared Lucas LefèvreiD· 2 shared Alessio AlfieriiD· 1 shared Alice Drake· 1 shared Anirudh PatiriD· 1 shared Antony D. AdamsoniD· 1 shared Anuj SehgaliD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersNeuroscience

Barry W. McCollORCID

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3 papers

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedMay 1, 2024

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

Anirudh Patir, Jack Barrington, Stefan Szymkowiak…·Barry W. McColl

This study examines how stroke alters myeloid cell composition and phenotypes in the brain, linking changes to cell origin, spatial organization, and brain connectivity.

19 citations

mousebulk RNA-seq

NeuroscienceeLifePeer-reviewedNov 6, 2023

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's Disease

Michael J. D. Daniels, Lucas Lefèvre, Stefan Szymkowiak…·Barry W. McColl

This study investigates the sex-specific role of Cst7 in microglia in an amyloid-driven Alzheimer's Disease model, finding sexually dimorphic effects on endolysosomal function and inflammation.

30 citations

mousebulk RNA-seq

Developmental BiologybioRxivPreprintSep 29, 2021

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling.

Jennifer Stables, Emma K. Green, Anuj Sehgal…·David Arthur Hume

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.

1 citation

mouseexperimental assay