Author

Marcus Q. Bernardini

University Health NetworkORCID 0000-0001-7022-8308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Arnaud DroitiD· 2 shared Catherine LachanceiD· 2 shared Charles Joly-BeauparlantiD· 2 shared Deepthi SudarshaniD· 2 shared Jacques CôtéiD· 2 shared Jean‐Philippe LambertiD· 2 shared Lara HerrmanniD· 2 shared Mikko TaipaleiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Arnaud DroitORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 11, 2026

Interplay of NuA4/TIP60 and PRC2 Complex Activities in Fusion Driven Endometrial Stromal Sarcoma

Deepthi Sudarshan, Charles Joly-Beauparlant, Stéphanie Bianco…·Jacques Côté

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

DOI 10.64898/2026.09.04.749526

humanexperimental assay

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Molecular BiologybioRxivMar 26, 2021

Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci

Deepthi Sudarshan, Nikita Avvakumov, Marie‐Eve Lalonde…·Jacques Côté

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

25 citations

humanDNA methylation

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