Catherine Lachance

This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.

This study investigates how NuA4/TIP60 complex acetylates and loads H2A.Z onto chromatin to regulate transcription, showing that acetylation precedes chromatin incorporation at promoters.

The paper identifies and characterizes multiple protein complexes associated with MRG15 and MRGX, revealing their roles in chromatin modification and transcription regulation.

This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.

The paper shows that the NuA4 complex controls nuclear-encoded photosynthesis genes in Arabidopsis, with loss of key components leading to chloroplast dysfunction and reduced chlorophyll levels.