Molecular BiologybioRxiv
Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci
Deepthi Sudarshan, Nikita Avvakumov, Marie‐Eve Lalonde…·Jacques Côté
This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.
25 citations