Cancer BiologybioRxivPreprint
Interplay of NuA4/TIP60 and PRC2 Complex Activities in Fusion Driven Endometrial Stromal Sarcoma
Deepthi Sudarshan, Charles Joly-Beauparlant, Stéphanie Bianco…·Jacques Côté
This study investigates the MBTD1-EZHIP fusion protein in LGESS, showing it forms a TIP60-PRC2 complex, reduces H3K27me3, and upregulates oncogenes, similar to JAZF1-SUZ12 but with distinct mechanisms.
DOI 10.64898/2026.09.04.749526