Eric D. Queathem

Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

Diet-Dependent Cognitive Benefits of Exogenous Ketone Body Precursor, (R,S)-1,3,-Butanediol, in a Mouse Model of Tauopathy

This study shows that (R,S)-1,3-butanediol improves memory in female tauopathy mice on chow but not on high-fat diets or after long-term use, highlighting sex and diet-dependent cognitive benefits.

Hepatic ketogenesis supports liver lipid homeostasis during acute exercise but is not required for exercise training to mitigate liver steatosis in mice

Ketone body driven lipid remodeling supports thermogenic adaptation to fasting

The paper shows that ketone bodies support thermogenic adaptation in BAT during fasting by promoting lipid remodeling and thermogenesis.

Ketogenesis protects against MASLD-MASH progression through mechanisms that extend beyond overall fat oxidation rate

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes

This study shows that PDK1 regulates triacylglycerol turnover in cardiomyocytes under nutrient deprivation, independent of its role in glucose metabolism.

Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomic Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment

This study uses multiomic analysis to investigate metabolic interactions between colorectal cancer cells and hepatocytes in liver metastasis, revealing metabolic shifts and potential therapeutic targets.

Ketogenesis supports hepatic polyunsaturated fatty acid homeostasis via fatty acid elongation

The paper shows ketogenesis supports PUFA homeostasis in hepatocytes by enabling FA elongation, and its disruption leads to lipid imbalances similar to MASLD.