Johannes Roth

This study identifies NR4A1 as a neutrophil-intrinsic regulator that reduces stroke severity by limiting inflammation and brain damage through pharmacological modulation.

This study shows immune cells enhance search efficiency by migrating along endothelial cell boundaries, increasing sampled cells per distance and chemokine sensitivity.

The paper shows that cytosolic S100A8/A9 is essential for neutrophil adhesion under flow by regulating Ca2+ availability at LFA-1 adhesion clusters.

This study shows NR4A1 reduces brain damage after ischemic stroke by limiting neutrophil activation and recruitment, with Cytosporone-B improving outcomes.

The paper identifies head-to-tail DNA template insertions in CRISPR/Cas9 editing and highlights the failure of PCR to detect them, advocating for comprehensive analysis.