Sabrina Simoncelli

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

This study shows PTPN22 regulates actin remodeling via PSTPIP-1 during T cell synapse formation, affecting TCR clustering and activation.

This study investigates how spike protein dynamics affect enveloped virus mobility using mesoscopic models and experimental validation.

This study shows that inhibiting Ephrin signaling disrupts stromal-cancer interactions and reduces metastasis in pancreatic cancer using mouse models.

This study shows that early HIV-1 maturation steps, specifically partial Gag cleavage, promote Env clustering and fusion competence by reorganizing the membrane-proximal lattice.

This paper introduces a DNA-PAINT system with optical photon reassignment on a spinning disk confocal to achieve high-resolution imaging in thick samples and large fields of view.

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.