Tsutomu Matsui

Computational design of a versatile, zero-radius proximity labeling enzyme

This paper designs a new proximity labeling enzyme, FlexID, using computational methods to improve spatial precision and versatility for mapping protein interactions and proteomes.

Unravelling the Maturation Pathway of a Eukaryotic Virus through Cryo-EM

This study uses cryo-EM to determine structural models of five intermediates in the maturation pathway of Nudaurelia capensis omega virus, revealing key structural changes during viral maturation.

Computational design of conformation-biasing mutations to alter protein functions

Contrastive scoring of protein variants across alternative backbone structures with inverse folding models (Conformational Biasing) predicts mutations that shift conformational equilibria and tune effector binding, catalysis, and labeling specificity.