Anna Laddach

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

The paper introduces TrajectoryGeometry to analyze cell fate decisions, finding that developmental pathways branch rather than bifurcate, with only cells taking the second branch making a decision.

The paper maps the regulatory landscape of neuronal and glial differentiation in the enteric nervous system using single-cell RNA sequencing and identifies gene modules and epigenetic memory associated with neurogenesis and gliogenesis.

A NeurIPS 2021 benchmarking competition evaluated over 2600 submissions from 280 competitors across three multimodal single-cell integration tasks using a purpose-built benchmarking dataset and cloud evaluation pipeline.

This study identifies molecular differences between pathogenic and population missense variants by analyzing their effects on protein structure and function, revealing distinct patterns in protein domains and cellular processes.

The paper integrates genetic and cell biological data from human iPSC lines to identify intrinsic and extrinsic factors driving inter-individual variability in cell behavior.

The paper develops an in-silico pipeline to analyze mutations and their effects on protein-protein interactions in acute myeloid leukaemia, identifying functional modules and potential drug targets.