Angela Hodges

This study identifies TREM2-dependent genes and pathways in Alzheimer's disease by analyzing RNA sequencing data from brain samples, revealing its impact on microglia, oligodendrocytes, and endothelial cells.

This study identifies seven novel genetic loci for Alzheimer's disease using a large GWAS and highlights microglia and immune pathways as key contributors to disease pathology.

The paper integrates lipidomics and proteomics data to identify modules associated with Alzheimer's disease phenotypes and risk loci in immune and lipid pathways.

This study compares transcriptomic profiles of asymptomatic and symptomatic Alzheimer's brains to identify early molecular changes associated with disease vulnerability.

ALSgeneScanner is a tool that provides automated, detailed reports on ALS-related gene variants from whole genome or exome sequencing data, aiding non-specialists in interpretation.

This study examines the transcriptional effects of Trem2 loss in mouse brain, revealing disruptions in cell co-expression networks and highlighting a potential role for Trem2 in endothelial cell homeostasis.

The paper assesses benign genetic variability in elderly individuals without neurodegenerative disease to aid in distinguishing pathogenic mutations.

This study uses Bayesian logistic regression to assess if genetic risk factors predict amyloid burden in non-demented individuals, finding that known factors like age and APOE are more predictive than polygenic risk scores.