Author

Hong Wang

Eli Lilly (United States)ORCID 0000-0002-9396-2334Unclaimed ORCID profile · follow to get notified of new preprints

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Hong Wang13 papers · Tongji University

Biology Disciplines

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Neuroscience· 3 Systems Biology· 1

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

David Andrew CollieriD· 3 shared Angela HodgesiD· 2 shared Charles A. MeiniD· 2 shared Eva L. WoźniakiD· 2 shared Guillermo CarbajosaiD· 2 shared John W. RyderiD· 2 shared Karim MalkiiD· 2 shared Kristie Wood· 2 shared

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2018-2021 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

David Andrew CollierORCID

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4 papers

Recent·Most cited

Microglia-specific promoter activities of human HexB gene

Sahil Shah, Lilly M. Wong, Kendra Ellis, Brittany Bondar, Sami Saribas, Julia Ting, Zhengyu Wei, Yuyang Tang, Xianwei Wang, Hong Wang, Binhua Ling, David M. Margolis, J. Víctor García, Wenhui Hu, Guochun Jiang

The paper identifies a microglia-specific promoter of the human HexB gene that can be used for AAV gene therapy targeting microglia in the CNS.

bioRxiv · Oct 28, 2021 · PreprintNeuroscience

TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer s disease

Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva L. Woźniak, Kristie Wood, Charles A. Mein, Alan Hodgkinson, Richard Dobson, David Andrew Collier, Michael J. O’Neill, Stephen Newhouse, Angela Hodges

This study identifies TREM2-dependent genes and pathways in Alzheimer's disease by analyzing RNA sequencing data from brain samples, revealing its impact on microglia, oligodendrocytes, and endothelial cells.

bioRxiv · Jul 16, 2021 · PreprintNeuroscience

Assessing 42 inflammatory markers in 321 control subjects and 887 major depressive disorder cases: BMI and other confounders and overall predictive ability for current depression

Timothy R. Powell, Helena Gaspar, Raymond Chung, Aoife Keohane, Cerisse Gunasinghe, Rudolf Uher, Katherine Jean Aitchison, Daniel Souery, Ole N Mors, Wolfgang Maier, Astrid W. Zobel, Marcella Rietschel, Neven Henigsberg, Mojca Zvezdana Dernovšek, Joanna Hauser, , Hong Wang

The paper evaluates 42 inflammatory markers in MDD cases and controls, finding strong confounding effects and limited predictive power of individual markers for MDD diagnosis.

bioRxiv · May 21, 2018 · PreprintNeuroscience

Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brain

Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva L. Woźniak, Kristie Wood, Charles A. Mein, Richard Dobson, David Andrew Collier, Michael J. O’Neill, Angela Hodges, Stephen Newhouse

This study examines the transcriptional effects of Trem2 loss in mouse brain, revealing disruptions in cell co-expression networks and highlighting a potential role for Trem2 in endothelial cell homeostasis.

Neurobiology of Aging · May 17, 2018Peer-reviewedSystems Biology