Akshay Kapadia

The paper shows that APP-CTFβ regulates glutamatergic synaptic transmission and that Aβ counteracts its hyperexcitability effects in Alzheimer's disease.

This paper presents a protocol for generating and using plasma membrane sheets to study membrane protein dynamics and synaptic vesicle recruitment in native membrane environments.

The paper shows that APP-CTFβ oligomers enhance synaptic vesicle tethering and release through C-terminal interactions, contributing to neuronal hyperactivity.

The paper introduces an extended SIM-Pull protocol to study synaptic protein complexes and vesicle recruitment using TIRF microscopy.

This paper develops a fluorescent probe to track PI(4,5)P2 dynamics in neurons, revealing that hallucinogenic ligands at the 5-HT2A receptor cause slower initial PI(4,5)P2 depletion compared to non-hallucinogenic ligands.