Manling Xie

The paper shows that impaired microglial phagocytosis due to TREM2 deficiency promotes seizure development in mice and correlates with seizure history in human patients.

This study shows that reducing Hv1 proton channels in macrophages improves antigen presentation and anti-tumor responses in glioma by altering macrophage behavior and immune response.

The paper identifies rod-shaped microglia in a TDP-43 mouse model that interact with neuronal dendrites to reduce cortical hyperexcitability and protect against neurodegeneration.

The paper identifies UDP-P2Y6 signaling as a key driver of microglial calcium activity, phagocytosis, and neuroinflammation during epileptogenesis.

The paper shows that higher TREM2 expression in gliomas correlates with poor prognosis, but TREM2 deficiency does not improve outcomes in pre-clinical models, as it impairs myeloid cell phagocytosis and MHCII-dependent CD4+ T cell responses.

This study shows spinal microglia amplify neuronal activity in inflammatory pain via the P2Y12 receptor, suggesting a therapeutic target for pain management.

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.

This study uses chemogenetic activation of microglial Gi DREADD to show reduced neuroinflammation and neuropathic pain in mice after spinal nerve injury.