Yong Liu

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

This study identifies tissue-specific and shared molecular adaptations to intermittent fasting in liver, brain, and muscle using proteomics and transcriptomics.

This study shows intermittent fasting changes chromatin accessibility and gene expression in brain and muscle tissues of mice, affecting metabolic and functional pathways.

This study shows that microglia regulate histamine-dependent and non-dependent itch transmission through distinct pathways, with histamine-dependent requiring the CX3CL1-CX3CR1 pathway.

This study identifies a novel interaction between TREM2 and TDP-43, showing TREM2 mediates microglial neuroprotection against TDP-43-related neurodegeneration.

This study shows that optogenetic activation of spinal microglia in mice induces chronic pain through IL-1 signaling and increased neuronal activity.

This study uses chemogenetic activation of microglial Gi DREADD to show reduced neuroinflammation and neuropathic pain in mice after spinal nerve injury.

This study investigates microglial calcium signaling in vivo, finding that microglial processes respond to changes in neuronal activity through calcium transients, while somatic calcium changes occur only after seizures.

This study shows that neuronal activity in awake mice influences microglial process surveillance via norepinephrine signaling, highlighting the need for awake imaging in studying microglia-neuron interactions.