Christoph B. Messner

The paper performs genome-wide association studies on 439 high-abundance serum proteins in 15,035 Scottish individuals, identifying 1,553 SNP signals and 13 putative causal protein-outcome associations.

The paper evaluates ZT Scan DIA, a proteomics method combining scanning DIA with ion trapping, showing improved precursor and protein identification, quantification, and bias reduction in multi-species mixtures.

The paper shows tuft cell IL-17RB limits IL-25 bioavailability, preventing excessive ILC2 activation and causing hypoproliferation under certain conditions.

The paper quantifies proteomic effects of aneuploidy in natural yeast isolates, finding chromosome-wide dosage compensation in the proteome but not transcriptome.

The paper records proteomes for non-essential gene knock-outs in yeast to uncover principles of protein expression and annotate gene function.

The paper shows yeast cells can cooperatively compensate for methionine auxotrophy by using a new homocysteine synthase, HSU1, to re-assimilate hydrogen sulfide.

The paper quantifies DNA modifications across diverse organisms and finds they are common in bacteria and higher eukaryotes but rare in yeast and insects.

OxoScan-MS enables sensitive and scalable glycoproteome profiling of plasma samples, revealing differential glycosylation in severe COVID-19 patients.

This paper introduces Scanning SWATH, a proteomics method that enables high-throughput quantification by using fast chromatographic gradients and improves precursor identification.

Neural-network ensembles scoring 69 peak features, plus fragment interference subtraction, boost data-independent acquisition (DIA) proteomics identifications and quantification precision, especially with short chromatographic gradients.