This study shows that blocking P2Y receptors with suramin prevents stress-induced RPE and photoreceptor degeneration in vitro and in a zebrafish model.

bioRxiv · May 28, 2024 · PreprintCell Biology

Biomarker Identification by Proteomic Analysis of Vitreous Humor and Plasma in Diabetic Retinopathy

Qian Huang, Angela Banks, Rebecca C. Stacy, Ning Li, Yesel Kim, Lori L. Jennings, Nancy Finkel, Stella Yao, Anfan Wu, Amy Chen, Ma’en Obeidat, Cynthia L. Grosskreutz, Shiao Hui Melissa Liew, Ganesh Prasanna, Hyeong Gon Yu, , Qin Zhang

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.

bioRxiv · May 18, 2024 · PreprintPhysiology

Double-stranded RNA induces retinal pigment epithelium cell degeneration and inflammation

Garrett Klokman, YongYao Xu, Kyle Bond, Xiaoqiu Wu, Joshua Schustak, Jorgi Mandelbaum, Michael Twarog, Hongwei Han, Mary-Kate Paulina, Matthew Coble, Christopher Hayden, Jean-Rene Galarneau, John Demirs, Yubin Qiu, Robert Esterberg, , Yi Bao

This study shows dsRNA triggers RIG-I signaling, leading to inflammation and RPE degeneration in AMD, with implications for pathogenesis.

bioRxiv · Mar 11, 2024 · PreprintCell Biology

A Proteogenomic Signature of Age-related Macular Degeneration in Blood

Valur Emilsson, Elias Freyr Gudmundsson, Þórarinn Jónmundsson, Brynjolfur G. Jonsson, Michael Twarog, Valborg Guðmundsdóttir, Zhiguang Li, Nancy Finkel, Stephen H. Poor, Xin Liu, Robert Esterberg, Yiyun Zhang, Sandra Jose, Chia Ling Huang, Sha-Mei Liao, , Tony E. Walshe

This study identifies a proteogenomic signature in blood associated with age-related macular degeneration, linking serum proteins to disease severity and progression.

Nature Communications · Jun 13, 2022Peer-reviewedGenetic & Genomic Medicine