Evan D. Rosen

This study uses snRNA-seq to analyze human adipose tissue depots, identifying distinct adipocyte and progenitor subpopulations and depot-specific intercellular communication networks, with changes observed in disease states.

This study identifies rapid remodeling of human subcutaneous white adipose tissue within one month after bariatric surgery using snRNA-seq, revealing changes in adipocyte populations and transcriptional dynamics.

The paper creates a single-cell transcriptome atlas of human subcutaneous adipose tissue vascular cells, identifies sub-AdECs, and links their properties to metabolic disease.

This study shows that mice exhibit persistent hyperphagia after a weight-loss intervention, with weight regain linked to initial weight gain on a high-fat diet.

The paper identifies obesity-related transcriptional changes in circulating extracellular vesicles and links them to adipose tissue epigenetics and inflammatory disease risk.

The paper uses single-nuclear RNA sequencing to analyze adipose tissue in lymphedema patients, identifying a stromal cell population that promotes lymphangiogenesis.

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.

This study investigates Ucp1-Cre expression in non-adipose tissues and finds it in epithelial cells during development, but not in adult mammary glands.

This study shows aging impairs beige adipogenesis and adipocyte metabolic responses to cold, identifies Npr3 as a marker gene, and provides insights into age-related adipose tissue dysfunction.

This study shows that mesothelial cells are not a source of visceral adipocytes in mice, challenging a recent paradigm based on Wt1 lineage tracing.