Cell BiologybioRxivPreprint
A multiplexed approach for genetic screening of human cells by electron microscopy uncovers a critical effector of mitochondrial cristae shape
Sarah Haßdenteufel, Yury S. Bykov, Benjamin Dubreuil…·Maya Schuldiner
The paper develops hMultiCLEM, a high-resolution screening pipeline combining EM and multiplexed human cell pools to identify proteins affecting mitochondrial cristae shape, uncovering MISHA linked to Meniere's disease.
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