Author

Klaske M. Schukken

Yale UniversityORCID 0000-0002-7311-2164Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jason M. SheltzeriD· 4 shared Pranav K. KandikuppaiD· 2 shared Zuzana ŠtorchováiD· 2 shared Alison Marie TayloriD· 1 shared Charles ZouiD· 1 shared Christopher R. VakociD· 1 shared Erik Marcel HelleriD· 1 shared Erin L. SausvilleiD· 1 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

Jason M. SheltzerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Systematic analysis of genetic vulnerabilities caused by chromosome loss events in cancer

Yi Bei, Jessica Keane, Mason Lynch, Kurt M. Tamaru, Suyeon Lee, Lu Qiao, Pranav K. Kandikuppa, Gregory Gauthier-Coles, Wenqi Zhao, Klaske M. Schukken, Ines Forrest, Sarah L. Thompson, Stephanie K. Roessler, Alison Marie Taylor, Jason M. Sheltzer

This study identifies genetic vulnerabilities from chromosome loss events in cancer by analyzing CRISPR screening data and copy number profiles, revealing paralogous gene dependencies as therapeutic targets.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines

Klaske M. Schukken, Saron M. Akalu, Charles Zou, Pranav K. Kandikuppa, Ryan A. Hagenson, Jessica L. Keane, Mason P. Lynch, Toyoki Yoshimoto, Olaf Klingbeil, Erin L. Sausville, Sanat Mishra, Christopher R. Vakoc, Zuzana Štorchová, Sarah J. Aitken, Jason M. Sheltzer

bioRxiv · Apr 28, 2026 · PreprintCancer Biology

Explainable Machine Learning Identifies Dosage Compensation Factors in Aneuploid Human Cancer Cells

Erik Marcel Heller, Karen Barthel, Markus Räschle, Klaske M. Schukken, Jason M. Sheltzer, Zuzana Štorchová

This study uses explainable machine learning to identify factors that buffer protein levels in aneuploid cancer cells, finding key predictors and implications for therapy.

Molecular Systems Biology · Jan 22, 2026Peer-reviewedCancer Biology

Extensive protein dosage compensation in aneuploid human cancers

Klaske M. Schukken, Jason M. Sheltzer

Across hundreds of human cancer cell lines, most proteins exhibit dosage compensation against chromosome copy number changes, buffering complex subunits, cell cycle genes, and even oncogenes and tumor suppressors.

bioRxiv · Jun 18, 2021 · PreprintGenomics