Stephen G. Young

The paper shows that endolysosomal damage leads to intraluminal protein condensates that prevent cytosolic leakage and sequester therapeutic oligonucleotides.

The paper introduces an automated AI pipeline for correlating chemical and ultrastructural images to enable organelle-specific molecular imaging in cells and tissues.

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

The age-related accumulation of progerin in smooth muscle cells (SMCs) explains the loss of arterial SMCs in Hutchinson-Gilford progeria syndrome.

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.