Peter Tontonoz

This study identifies SCD as a lipid metabolic checkpoint that regulates macrophage activation and plasticity by maintaining lipid desaturation balance and preventing pro-inflammatory responses.

This paper introduces POCA, a photosensitizer-based proximity labeling method that captures both protein and lipid interactomes with high spatiotemporal resolution.

This study identifies NK2R as a key regulator of intestinal lipid metabolism and mucosal inflammation, showing bidirectional effects on lipid mobilization and immune responses.

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

This study shows that vertical sleeve gastrectomy in mice reduces plasma cholesterol without weight loss by enhancing bile acid synthesis and hepatobiliary elimination.

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

The paper identifies cholesterol binding to VCAM-1 as a mechanism promoting vascular inflammation by stabilizing VCAM-1 and enhancing immune cell recruitment.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

This study identifies PATZ1 as an adipogenic transcription factor that promotes adipogenesis through DNA binding and protein interactions, and its loss protects against diet-induced obesity.

This study shows that loss of TLE3 enhances mitochondrial function in beige adipocytes, improves glucose metabolism, and prevents weight gain.