Author

Gu Chen

University of Hong Kong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Di CuiiD· 2 shared Haibo Jiang· 2 shared Hui YangiD· 2 shared Kaiqiang ZhaoiD· 2 shared Mehran NikaniD· 2 shared Punit P. SethiD· 2 shared Stephen G. YoungiD· 2 shared C. Frank BennettiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Di CuiORCID

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Author profile →

3 papers

Recent·Most cited

Endolysosomal damage promotes intraluminal protein condensate formation that limits cytosolic leakage

Xu Li, Yu Zhang, Kaiqiang Zhao, Gu Chen, Di Cui, Mehran Nikan, Stephen G. Young, Frank C. Bennett, Punit P. Seth, Tao Ni, Maximiliano Gabriel Gutierrez, Haibo Jiang

The paper shows that endolysosomal damage leads to intraluminal protein condensates that prevent cytosolic leakage and sequester therapeutic oligonucleotides.

bioRxiv · May 25, 2026 · PreprintCell Biology

Automated Multimodal Correlative Registration for Organelle-Specific Molecular Imaging

Chixiang Lu, Kaiqiang ZHAO, Di Cui, Gu Chen, Qian Yang, Hui Yang, Murong Zhao, Kaiyun Song, Mehran Nikan, Zhijie Li, Shanchao Zhao, Jinpeng Cen, Xincheng Qiu, Stephen G. Young, C. Frank Bennett, , Haibo Jiang

The paper introduces an automated AI pipeline for correlating chemical and ultrastructural images to enable organelle-specific molecular imaging in cells and tissues.

bioRxiv · May 4, 2026 · PreprintBioinformatics

In vivo Calcium Imaging in the Near-Infrared II Window

Danyang Xu, Zhisheng Wu, Hui Yang, Gu Chen, Wayne Jason Li, Xingyu Yue, Guang-Lei Wang, Sixin Xu, Hanze Yu, Yuanhua Liu, Zideng Dai, Haibo Jiang, Long-Jiang Yu, Hongjie Dai, Feifei Wang

This paper develops a near-infrared II calcium imaging technique using a bacterial protein to enable high-sensitivity, non-invasive deep-tissue calcium imaging in live mammals.

Journal of the American Chemical Society · Dec 24, 2025Peer-reviewedBioengineering