Xiao Xu

Lipid- and protein-directed photosensitizer proximity labeling captures the cholesterol interactome

This paper introduces POCA, a photosensitizer-based proximity labeling method that captures both protein and lipid interactomes with high spatiotemporal resolution.

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

Cholesterol Metabolism in a Murine Model of Vertical Sleeve Gastrectomy

This study shows that vertical sleeve gastrectomy in mice reduces plasma cholesterol without weight loss by enhancing bile acid synthesis and hepatobiliary elimination.

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.