Marc J. P. M. Tol

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

A cold-inducible phospholipid--protein interaction in brown fat mitochondria optimizes thermogenic capacity

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

Cholesterol binding to VCAM-1 promotes vascular inflammation

The paper identifies cholesterol binding to VCAM-1 as a mechanism promoting vascular inflammation by stabilizing VCAM-1 and enhancing immune cell recruitment.