Author

Sascha Röth

University of DundeeORCID 0000-0001-7273-6701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Gopal P. SapkotaiD· 3 shared Thomas MacartneyiD· 3 shared Arjan Buist· 2 shared Diederik Moechars· 2 shared Gajanan J. SatheiD· 2 shared Géraldine GeldersiD· 2 shared Louis De MuynckiD· 2 shared Abigail Brewer· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

Gopal P. SapkotaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologyScientific ReportsPeer-reviewedSep 15, 2026

Data-independent acquisition (DIA) approach for comprehensive ubiquitinome profiling in targeted protein degradation

Gajanan J. Sathe, Sascha Röth, Géraldine Gelders…·Gopal P. Sapkota

This study develops a DIA-based workflow for comprehensive ubiquitinome profiling in targeted protein degradation, identifying over 40,000 ubiquitylated peptides.

DOI 10.1038/s41598-026-69423-4

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 15, 2025

Targeted degradation of α-synuclein prevents PFF-induced aggregation

Bill Carton, Géraldine Gelders, Gajanan J. Sathe…·Gopal P. Sapkota

This study demonstrates targeted degradation of α-synuclein using a nanobody-guided system, preventing PFF-induced aggregation in neurons.

2 citations

ratprotein structure

𝕏 PostBluesky

Molecular BiologyCell chemical biologyPeer-reviewedJul 14, 2020

Targeting endogenous K-RAS for degradation through the affinity-directed protein missile system

Sascha Röth, Thomas Macartney, Agnieszka Konopacka…·Gopal P. Sapkota

This paper demonstrates the degradation of endogenous K-RAS and H-RAS using an AdPROM system, offering a new approach for targeting undruggable cancer proteins.

64 citations

humanexperimental assay

𝕏 PostBluesky