Author

Sabrina Koseki

MIT Media LabORCID 0000-0001-7273-970XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Emma TysingeriD· 2 shared Garyk BrixiiD· 2 shared Kalyan Palepu· 2 shared Pranam ChatterjeeiD· 2 shared Suhaas BhatiD· 2 shared Teodora StaniD· 2 shared Bennett K. WolfiD· 1 shared Christian Clark KrammeiD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersDevelopmental Biology

Emma TysingerORCID

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2 papers

Recent·Most cited

Rapid Human Oogonia-like Cell Specification via Combinatorial TF-Directed Differentiation

Christian Clark Kramme, Merrick Pierson Smela, Bennett K. Wolf, Patrick R.J. Fortuna, Garyk Brixi, Kalyan Palepu, Edward Dong, Jessica Adams, Suhaas Bhat, Sabrina Koseki, Emma Tysinger, Teodora Stan, Richie E. Kohman, Songlei Liu, Mutsumi Kobayashi, , Pranam Chatterjee

This study identifies key transcription factors that drive the rapid differentiation of human induced pluripotent stem cells into oogonia-like cells using a combinatorial approach and computational tools.

bioRxiv · Jul 11, 2022 · PreprintDevelopmental Biology

Design of Peptide-Based Protein Degraders via Contrastive Deep Learning

Kalyan Palepu, Manvitha R. Ponnapati, Suhaas Bhat, Emma Tysinger, Teodora Stan, Garyk Brixi, Sabrina Koseki, Pranam Chatterjee

This paper designs peptides to degrade undruggable proteins using contrastive deep learning and experimental validation in human cells.

bioRxiv · May 23, 2022 · PreprintSynthetic Biology