Author

Emma Tysinger

MIT Media LabORCID 0000-0002-3958-8097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1

Frequent Co-Authors

Garyk BrixiiD· 3 shared Pranam ChatterjeeiD· 3 shared Christian Clark KrammeiD· 2 shared Edward Dong· 2 shared George McDonald ChurchiD· 2 shared Kalyan Palepu· 2 shared Merrick Pierson SmelaiD· 2 shared Mutsumi KobayashiiD· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Garyk BrixiORCID

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Author profile →

3 papers

Recent·Most cited

Directed Differentiation of Human iPSCs to Functional Ovarian Granulosa-Like Cells via Transcription Factor Overexpression

Merrick Pierson Smela, Christian Clark Kramme, Patrick R.J. Fortuna, Jessica L Adams, Rui Su, Edward Dong, Mutsumi Kobayashi, Garyk Brixi, Venkata Srikar Kavirayuni, Emma Tysinger, Richie E. Kohman, Toshi Shioda, Pranam Chatterjee, George McDonald Church

This study generates functional ovarian granulosa-like cells from human iPSCs by overexpressing NR5A1 and RUNX1 or RUNX2, enabling the formation of ovary-like organoids with germ cells.

eLife · Jan 19, 2023Peer-reviewedDevelopmental Biology

Rapid Human Oogonia-like Cell Specification via Combinatorial TF-Directed Differentiation

Christian Clark Kramme, Merrick Pierson Smela, Bennett K. Wolf, Patrick R.J. Fortuna, Garyk Brixi, Kalyan Palepu, Edward Dong, Jessica Adams, Suhaas Bhat, Sabrina Koseki, Emma Tysinger, Teodora Stan, Richie E. Kohman, Songlei Liu, Mutsumi Kobayashi, , Pranam Chatterjee

This study identifies key transcription factors that drive the rapid differentiation of human induced pluripotent stem cells into oogonia-like cells using a combinatorial approach and computational tools.

bioRxiv · Jul 11, 2022 · PreprintDevelopmental Biology

Design of Peptide-Based Protein Degraders via Contrastive Deep Learning

Kalyan Palepu, Manvitha R. Ponnapati, Suhaas Bhat, Emma Tysinger, Teodora Stan, Garyk Brixi, Sabrina Koseki, Pranam Chatterjee

This paper designs peptides to degrade undruggable proteins using contrastive deep learning and experimental validation in human cells.

bioRxiv · May 23, 2022 · PreprintSynthetic Biology