Songlei Liu

The paper introduces a machine-learning pipeline, CellCartographer, to design TF pooled-screens for cell type conversion using chromatin accessibility data, achieving efficient differentiation of iPSCs into six cell types within 6 days.

This study identifies mouse transcripts in human cells from xenograft models and confirms in vitro mRNA transfer from mouse to human cells.

The paper demonstrates multiplex base editing to convert TAG to TAA codons in 33 essential human genes and introduces a computational tool for recoding.

This study identifies key transcription factors that drive the rapid differentiation of human induced pluripotent stem cells into oogonia-like cells using a combinatorial approach and computational tools.

The paper identifies cell type specific driver genes in autism-associated copy number loci using cerebral organoids and validates findings with CRISPR/Cas9-edited mosaic organoids.

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

The paper introduces BOLORAMIS, a RT-free method for spatially-resolved, targeted in-situ RNA detection, and demonstrates its use on human iPSCs to identify spatial localization and expression heterogeneity.