Alexander Blume

This study identifies IDHA-1 as a barrier to direct reprogramming of germ cells to neurons in C. elegans, showing metabolic and epigenetic mechanisms that maintain germ cell identity.

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.

The paper presents reproducible genomics analysis pipelines using GNU Guix for RNA-seq, ChIP-seq, Bisulfite-seq, and single-cell RNA-seq, ensuring consistent results across different environments.

This paper reviews techniques and software for analyzing bisulfite sequencing data, focusing on quality checks, differential methylation, segmentation, and annotation methods.