Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression
Chen Wang, Yi Pan, Ruochen Dong, Wenxuan Zhou, Xiaduo Meng, Yao Shi, Ravi Nistala, Richard Hammer, Linheng Li, Xunlei Kang
This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.
bioRxiv · Jun 29, 2024 · PreprintCancer Biology