Ruochen Dong

The paper identifies pre-hematopoietic stem cells and their niche using spatial transcriptomics in the AGM region, revealing spatial signaling patterns and cellular interactions that support HSC development.

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

This study identifies two distinct multicellular niches in fetal liver and adult bone marrow that support hematopoietic stem cells with different cycling states and lineage biases.

This study shows that deleting the IFT-A gene Thm1 in ADPKD mouse models has development-specific effects on kidney cysts, inflammation, and cilia length, suggesting environmental factors influence ciliary homeostasis and disease progression.

This study shows that Thm1 deletion in juvenile Pkd2 mice worsens biliary development and PLD, while adult Thm1 deletion has no effect, highlighting distinct roles of IFT-A and IFT-B in liver disease.