Linheng Li

The paper identifies pre-hematopoietic stem cells and their niche using spatial transcriptomics in the AGM region, revealing spatial signaling patterns and cellular interactions that support HSC development.

This study identifies DCLK1's role in regulating invadopodia dynamics and MMP trafficking in HNSCC, showing its impact on invasion and metastasis.

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

This study identifies two distinct multicellular niches in fetal liver and adult bone marrow that support hematopoietic stem cells with different cycling states and lineage biases.

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.