Leo P. Sugrue

This study shows that therapeutic DBS for OCD suppresses BOLD activity in the default mode network compared to non-therapeutic configurations.

The paper examines how educational opportunity affects white matter development in adolescents, finding it correlates with accelerated development in academic-related tracts after controlling for socioeconomic factors.

The paper identifies a C9orf72 gene network correlated with cortical thickness in C9-FTD and implicates vulnerable cell types.

The paper examines the relationship between white matter properties and reading skill development using longitudinal and cross-sectional data, finding that reading skill gains correspond to longitudinal white matter changes but not individual differences in white matter.

The paper investigates C9orf72 expansion carriers using radiogenomics to link peripheral blood transcriptomics with thalamic atrophy and clinical impairment, finding global transposable element de-repression and associations between C9orf72 expression and disease severity.

The paper uses restriction spectrum imaging to analyze age-related microstructural changes in brain diffusion across 9-14 year olds from the ABCD Study, finding increased restricted diffusion in subcortical regions with age.

The paper uses RSI to analyze diffusion patterns in subcortical regions of children aged 9-13, finding age-related changes in restricted diffusion metrics across different brain areas.

The paper describes neuroimaging processing methods for the ABCD Study to extract brain phenotypes from multimodal imaging data.

This study identifies genetic variants and networks associated with ALS using GWAS data, revealing novel loci and functional sub-networks linked to disease.

The paper identifies genetic variants associated with Alzheimer's disease and cardiovascular risk factors, showing lipid-related enrichment and pleiotropy beyond APOE.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.

This study evaluates whether a polygenic hazard score (PHS) can enhance the prediction of amyloid and tau deposition and progression to Alzheimer’s dementia when combined with biomarkers in nondemented individuals.

The paper shows that deviations from the matching law in foraging behavior reflect an optimal strategy using multi-timescale learning to balance bias and variance under uncertainty.