Murray Grossman

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

This study investigates how TMEM106B and C9orf72 genetic variants influence TDP-43 pathology in ALS and FTLD-TDP, finding TMEM106B modifies TDP-43 aggregation severity.

Joint ex vivo MRI and histology detect iron-rich cortical gliosis in Tau and TDP-43 proteinopathies

This study uses joint ex vivo MRI and histology to identify distinct iron-rich gliosis patterns in FTLD-Tau and FTLD-TDP, distinguishing them from other neurodegenerative conditions.

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration

This paper evaluates the ATN framework's accuracy in diagnosing Alzheimer's disease subtypes and frontotemporal lobar degeneration using cerebrospinal fluid biomarkers, finding that non-amnestic Alzheimer's patients have lower tau levels and the framework is less sensitive to frontotemporal lobar degeneration.

CXCR4 involvement in neurodegenerative diseases

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

Neural coding of fine-grained object knowledge in perirhinal cortex

The paper investigates how perirhinal cortex encodes semantic knowledge of objects by dissociating perceptual features from semantic meaning using fMRI and multivoxel-pattern analysis.