PhysiologyNature CommunicationsPeer-reviewed
Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels
Reem Handklo‐Jamal, Tal Keren Raifman, Boris Shalomov…·Nathan Dascal
The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.
DOI 10.1038/s41467-025-66730-8