Daniel Yakubovich

This study identifies conserved transcriptomic signatures in GNB1 encephalopathy across human and mouse models, linking GNB1 mutations to developmental, epileptic, and neuronal dysfunction.

The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.

This study identifies ethosuximide as a subunit-selective, Gβγ-dependent blocker of GIRK channels, revealing its mechanism of action and potential as a therapeutic tool.

This study examines EEG and behavioral changes in Dravet syndrome mice across disease stages, finding reduced EEG power and early behavioral deficits.