Haritha P. Reddy

This study identifies conserved transcriptomic signatures in GNB1 encephalopathy across human and mouse models, linking GNB1 mutations to developmental, epileptic, and neuronal dysfunction.

The paper shows Gβγ interacts with GIRK2 and GIRK1/2 channels with affinities in the microM range, with GIRK1/2 having higher apparent affinity due to a unique Gβγ docking site.

This study identifies ethosuximide as a subunit-selective, Gβγ-dependent blocker of GIRK channels, revealing its mechanism of action and potential as a therapeutic tool.

This study identifies GNB1 mutations causing neurodevelopmental disorder and shows ethosuximide effectively treats symptoms in mouse and cellular models.