Biosensor Cell Array Reveals Temporal GABA Secretion Dynamics from Pancreatic Islets
Austin E. Stis, Charles S Lazimi, Sandra M. Ferreira, Alexandra E. Cuaycal, Dylan Smurlick, D. Walker Hagan, Taylor Nakayama, Sunil Gandhi, Emery Smith, Timothy Spicer, Edward A. Phelps
The paper reveals that GABA secretion from pancreatic beta cells occurs via the LRRC8A/D VRAC channel and is coordinated with calcium influx and depolarization, not vesicular release or insulin secretion.
Molecular Metabolism · Sep 25, 2026Peer-reviewedPhysiology