Nuclear Localization Signals Enable the Cellular Delivery of an Anti-CRISPR Protein to Control Genome Editing
Axel O. Vera, Franklin J. Avilés-Vázquez, Taekjip Ha, Amit Choudhary, Ronald T. Raines
This paper develops a cell-permeable anti-CRISPR protein (6xNLS-Acr) that efficiently inhibits Cas9 activity in human cells, enhancing genome-editing specificity.
Journal of the American Chemical Society · Sep 4, 2026Peer-reviewedGenomics