Author

Axel O. Vera

Broad InstituteORCID 0000-0003-4522-2793Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Amit ChoudharyiD· 2 shared Ronald T. RainesiD· 2 shared Bradley L. PenteluteiD· 1 shared Franklin J. Avilés-VázqueziD· 1 shared Nicholas L. TruexiD· 1 shared Taekjip HaiD· 1 shared Vedagopuram SreekanthiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersGenomics

Amit ChoudharyORCID

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2 papers

Recent·Most cited

GenomicsJournal of the American Chemical SocietyPeer-reviewedSep 4, 2026

Nuclear Localization Signals Enable the Cellular Delivery of an Anti-CRISPR Protein to Control Genome Editing

Axel O. Vera, Franklin J. Avilés-Vázquez, Taekjip Ha…·Ronald T. Raines

This paper develops a cell-permeable anti-CRISPR protein (6xNLS-Acr) that efficiently inhibits Cas9 activity in human cells, enhancing genome-editing specificity.

DOI 10.1021/jacs.5c19089

humanCRISPR screen

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedAug 4, 2025

Protective antigen-mediated delivery of an anti-CRISPR proteinfor precision genome editing

Axel O. Vera, Nicholas L. Truex, Vedagopuram Sreekanth…·Ronald T. Raines

This paper develops a protein-based delivery system for anti-CRISPR proteins to precisely control Cas9 activity, reducing off-target effects and improving genome editing specificity.

7 citations

humanCRISPR screen

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