Martin Jacko

This paper introduces LATeNT, a light-activated tetanus neurotoxin that enables conditional proteolysis and inducible synaptic inhibition in vivo, with applications in neuroscience and beta cell function.

The paper develops SpliceRUSH, a high-throughput screening method to map splicing-regulatory elements in their native sequence context, identifying both known and novel SREs in the SMN2 gene.

The paper identifies early- and late-switch exons in neural development and shows they are regulated by RNA-binding proteins, with some neuronal subtypes lacking these regulators and retaining an immature splicing program.