Huijuan Feng

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

The paper uses single-cell transcriptomes to reverse engineer splicing-regulatory networks specific to and orthogonal of neuron types, identifying key RNA-binding proteins and regulatory modules.

The paper uses scRNA-seq to analyze alternative splicing regulation across neuronal cell types, revealing distinct splicing programs and RBPs involved in graded regulation.

The paper develops a computational method, mCross, to model RBP binding specificity using precise crosslink site registration and validates it with ENCODE eCLIP data.

The paper analyzes RNA-Seq data to characterize kinase gene expression and splicing in prostate cancer, identifying isoform switching in CDK5 that affects AR phosphorylation.

The paper identifies early- and late-switch exons in neural development and shows they are regulated by RNA-binding proteins, with some neuronal subtypes lacking these regulators and retaining an immature splicing program.